If M. azedarach is controlled during the early stages of establishment, the potential for successful management is high. The potential for large-scale restoration of wildlands where it has already become established, however, is probably lower due to requirements for longer-term efforts. The best control of M. azedarach, as reported by land stewards/managers, occurs with the appropriate use of chemical methods.

Chemical: In an article describing herbicide control measures for many of the invasive exotic species in Florida, Kline and Duquesnel (1996) recommend the following methods, herbicides and equipment, for the chemical control of M. azedarach. For basal bark treatments (which can be applied to a range of stem sizes, from saplings to large trees) the use of 10% Garlon 4 is recommended. A back-pack sprayer, spray gun or a hand-held spray bottle can be used for application. For cut-surface treatment (which could be tree-injection, girdle (frill) method or a cut stump treatment) the use of 50% Garlon 3A is recommended. Back-pack sprayers or pump-up sprayers are suitable for cut-surface treatments. For foliar spray 1% (high volume) Garlon 3A is recommended. The authors report that the effectivness of the basal bark and cut-surface treatments are 'excellent' and that of the foliar spray is 'good'.

Mechanical: The authors of a study into the clonal strategies of M. azedarach state that injury to the plant, by animal-mediated injury at a local scale or by fire on a large scale induced prolific resprouting - thus increasing the density and spread of the species. The authors demonstrate that excised roots initiate the development of adventitious buds and suckers (Tourn et al. 1999).